At present, there are about 81 kinds of anti-tumor drugs commonly used clinically. 1. Anti-tumor drugs are classified according to their source and mechanism of action. Generally divided into alkylating drugs, antimetabolites, antibiotics, plants, hormones and other drugs. Other drugs include platinum, asparaginase, targeted therapy drugs, etc., excluding biological reagents and gene therapy. This classification cannot summarize the current development of anti-tumor drugs. Second, the other classification is based on the molecular targets of drugs, which are divided into many categories. The first category is drugs that act on the chemical structure of DNA, such as alkylating or platinum compounds. The second category is drugs that affect nucleic acid synthesis, such as antimetabolites. The third category is the drug that acts on the DNA template, affects the transcription and inhibition of DNA, and inhibits RNA synthesis by relying on RNA polymerase. The fourth category is drugs that affect protein synthesis, such as paclitaxel, vinblastine and so on. The last category is other types of drugs, such as hormones, aspartic acid, targeted therapy drugs, etc., but the current anti-tumor drugs are developing rapidly, and the above categories can not summarize the existing drugs and the drugs that are about to enter the clinic. . “

At present, there are many anti-tumor drugs in clinical practice. For example, oxaliplatin, fluorouracil, and irinotecan can be used for gastrointestinal tumors. Patients with gastric cancer can be treated with drugs such as cisplatin and paclitaxel. In general, different cancers choose different drugs. In addition, cancer patients can also be treated with molecular targeted drugs, such as erlotinib, osimertinib, cetuximab and other drugs

Common anti-tumor drugs that cause CIPN include Paclitaxel, Platinum, Vinblastine, Methotrexate, Fluorouracil, Ifosfamide, Cytarabine, Fludarabine, Thalidomide, Bortimiazole and so on.

Paclitaxel uses nerve growth factor to reduce or reverse neurotoxicity; cisplatin uses reduced glutathione and amifostine to prevent neuropathy caused by it; oxaliplatin does not contact cold stimulation during use to prevent cold stimulation from affecting peripheral nerves Stimulation, the use of calcium-magnesium mixture can reduce the incidence and intensity of acute neurotoxicity symptoms, and delay the occurrence of cumulative neuropathy; ifosfamide can choose methylene blue to prevent neurotoxicity; use thiamine for fluorouracil may prevent nerves Toxic effect.

Post time: Sep-15-2020